Love the 49ers in this spot. I generally lean to dogs and road teams in the NFL and this fits the ball. 49ers have the better defense here. Saints have the better QB but he will struggle against that nasty San Fran defensive line. The Ravens were putting up 40 points on everyone and they only scored 20 at home vs San Fran.
If i were Kyle Shanahan I would run the ball often to eat clock, keep Drew Brees off the field and most importantly keep that raucous crowd quiet. If Jimmy G limits his fumbles and INT's then 49ers win.