Could a Gene Mutation be Causing Depression?

I found out a couple years ago about a gene mutation that can cause depression. I can't believe how much mental illness could be related to this gene mutation. Here is a link to an article by Psychology Today that explains more:


Crazy how many people are at risk for having this mutation and it's never talked about. A simple blood test would discover it, yet in my experience with psychiatrists they rarely consider diet and hormones let alone this gene mutation.

I kind of love the abbreviation for this gene mutation and seems appropriate for how much this mutation can affect your mental and physical health. It's like having me as a mutation is a motherf*cker πŸ˜…πŸ˜‚πŸ€£

My health insurance is super expensive and it's an HSA so expensive to go the Dr. So I did not get tested I found the supplement for about $10 for a 2 month supply and figured why not try taking it, I've struggled with depression and digestive issues since I was a child, if this can help, what to I have to lose?

Here is the supplement I started taking.

Here is another supplement I started taking because the methylated version is supposed to be easier for the body to absorb. With the amount of exhaustion I was experiencing I needed a boost.

I have to say I notice a significant difference in my mood and thoughts. I am still dealing with anxiety and it's getting better, and the depression is gone, I am consistently able to see the bright side of things and pull myself out of the dark feelings depression can have. I feel hopeful and upbeat 95% of the time now. I have also changed my job which is huge and been more selective with who I spend time with.

I believe it's all connected and if you have a mutation isn't it great a $10 supplement can make a world of a difference? Anyone else have this gene or experience with this?

I am full on immersed in my healing and I am so grateful for the tools and environment to do so πŸ’œπŸ™πŸ»πŸ’•

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09.10.2019 15:41

I am pretty sure the treatment for depression is very much to search in nutrition, hormones and bacteria. But that doesn’t fill the wallets of psychiatrists and pharma companies, so it is held back!
Good to hear about your progress, running or other sports helps for me too!

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09.10.2019 15:52

Thanks for the feedback! Yeah for real, and weird because doctors could sell supplements and make money which I was thinking about when reading this... problem is they don't want people well, they fear losing money. It's crazy to me! Thank you, yes I love hiking and walking and dancing and that really helps me too. Thanks for stopping by πŸ’œπŸ™πŸ»

10.10.2019 02:59

Interesting post. The trend for the production of new b complex is encouraged by recent findings in the field of in vitro colon stimulation. Genomic research and biota are the center of attention right now when it comes to what you mentioned and hot in general medicine practice. epigenetics and how the biota and other microbial genomes affect us reveals bizarre evidence that makes us rethink our conventionally synthesized pharmaceuticals, neutraceuticals, other phytopharma or nutritional supplements. Fresh kurkuma root in a smoothie seems to work for me during my downs. Mostly its this time of the year, the weather and most people don't admit, wont realise or simply attribute it to something deterministic.

09.10.2019 17:37

Thanks so much for the feedback! I am very interested in epigenetics, I love the work Bruce Lipton is doing and need to go reread his book. This is a great reminder. I've never heard of kurkuma, time for me to google πŸ˜€ where do you get it? I completely agree about this time of year and have realized that it happens every year so maybe this seasonal depression thing is for real! I try and get outside as much as possible too. I also think the pain of the collective consciousness during the holiday season is felt by empaths and awakened people too. Thanks for stopping by πŸ™πŸ»πŸ’œπŸ’•

10.10.2019 02:50

Kurcuma.... I think they mean turmeric.

10.10.2019 06:36

Ahh yes! That makes sense

10.10.2019 23:07

Yeah I’m glad you brought that up.


And yeah, epigenetics. If triggers turn these genes on, we know triggers can also turn them off. We just don’t quite know how.... yet!

10.10.2019 06:35

Be interested in your view of this @metametheus! Fascinating. Glad you are feeling a bit better. Depression sucks.

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10.10.2019 03:25

Ok, so I’m not up on the MOFO gene mutation, but know about it from Naturopath colleagues, coz they bang on about it all the time. An interesting fact I just came across.... there is a higher than usual incidence in Downs Syndrome cohort of this mutation also... or was that Autism...? Hmmm, can’t remember now, it was one of the two.


TCM theory considers that most of the root of depression comes from the Liver organ-system failure to β€œdredge the channels” and ensure the free-flow of QΓ¬. A previous colleague of mine I used to work alongside believes this is what we know as the cytochrome pathways of the liver β€” in other words, the chemical pathways that the liver uses to detoxify the body (blood).

Which involves the liver doing all of the things with Vitamin B and all those other nutrients.

Which people with the MOFO mutation struggle with, which is why they need methylated forms of some substances (like Vitamin B).

So yeah, makes complete sense to me. That was mostly my argument and approach when it came to treating Depression: cleanse and detoxify. No need for psych meds. Not a popular opinion, as you can imagine.

10.10.2019 06:34

That makes so much sense to me, if our liver is clogged how can we feel good mentally?
I agree, first address the physical things then the mental part can reveal what it really needs. Dr's hand our anti depressants like they hand our birth control. It's crazy to me how over medicated many in society are. Thanks for stopping by πŸ™πŸ»πŸ’œ

10.10.2019 23:05

Thank you!! So many factors at play with depression and I am grateful for support, information, and tools πŸ’œπŸ™πŸ»

10.10.2019 11:48

Interesting, I'm going to have to check out the Psychology Today article. If it's finally getting recognized as A Thing by traditional "western" practitioners, that's a big step. When I looked into it a couple of years ago, pretty much it was: natural living sites saying it's a thing, and western medicine sites saying it was hokum.

11.10.2019 00:15

Sorry I missed this! Broke my phone and had to return the new phone lol. Anyway, it's awesome that people are starting to wake up to the many aspects of diseases and not just a pill that masks the issues. It really works for me and even if it's a placebo effect I don't care lol! It works and I'm grateful :)

27.10.2019 02:36